Scientific references
 

Scientific articles
 
   List of scientific references describing applications of GENOVAC antibodies (49 KB)
 
09/10Fofana I et al (2010): Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes. Gastoenterology 139(3), 953-964.
  
08/10Kanderova V et al (2010): Aberrantly expressed CEACAM6 is involved in the signaling leading to apoptosis of acute lymphoblastic leukemia cells. Exp Hem 38/8, 653-660.
  
04/10Krieger SE et al (2010): Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations. Hepatology, 51/4:1144-57
  
03/10Abrami L et al (2010): Endocytosis of the Anthrax toxin is mediated by Clathrin, Actin and unconventional adaptors. PLoS Pathog. 2010 March; 6(3): e1000792.
  
01/10Singer B et al (2010): Deregulation of the CEACAM Expression Pattern Causes Undifferentiated Cell Growth in Human Lung Adenocarcinoma Cells. PLoS One. 2010; 5(1): e8747
  
09/09Carvalho, FA et al (2009): Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. JEM, 206/10: 2179-2189.
  
07/09Adler H et al (2009): Perturbation of Lytic and Latent Gammaherpesvirus Infection in the Absence of the Inhibitory Receptor CEACAM1. PLoS ONE 4/7
  
07/09Yue T et al (2009): The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Mol Cell Proteomics. 8(7): 1697-707.
  
05/09Porotto M et al (2009): Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol., 83(10): 5148-55.
  
02/09Semiramoth N et al (2009): Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase -and MAPK- dependent mechanism. J Leukocyte Biol, 85, 1-12
  
01/09Guignot J et al. (2009): Human Decay-Accelerating Factor and CEACAM Receptor-Mediated Internalization and Intracellular Lifestyle of Afa/Dr Diffusely Adhering Escherichia coli in Epithelial Cells. Infection and Immunity, 77/1, 517-531
  
12/08Polymenidou M et al. (2008): The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes. PLoS ONE ; 3/12: e3872.
  
12/08Porada CD et al (2008): Development and characterization of a novel CD34 monoclonal antibody that identifies sheep hematopoietic stem/progenitor cells. Exp Hematol, 36/12: 1739-1749
  
11/08Beaslas O et al (2008): Transcriptome response of enterocytes to dietary lipids: impact on cell architecture, signaling, and metabolism genes. Am J Physiol Gastrointest Liver Physiol, 295/5: G942-52
  
06/08Thomas SN et al. (2008): Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow. J Biol Chem, 283: 15647-55.
  
07/08Paulmann D et al. (2008): Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation. J Gen Virol 89, 1593-1604
  
06/08Planagumà A et al (2008): Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma. Am J Respir Crit Care Med, 178: 574–582
  
02/08Björkman L et al (2008): Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1. J Leukoc Biol, 83: 245-53
  
12/07Yoon J et al (2007): CD66b Regulates Adhesion and Activation of Human Eosinophils. J Immunol, 179: 8454-62
  
12/07Zeisel M et al. (2007): Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology, 46/6:1722-31
  
12/07Riesenberg R et al (2007): Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal CellCarcinoma. Clin Cancer Res, 13/23, 6993-7002
  
08/07Catanese MT et al. (2007): High avidity monoclonal antibodies against human scavenger receptor class B type I efficiently block hepatitis C virus infection in the presence of HDL. J Virol, 81/15, 8063-8071.
  
06/07Bonn S et al (2007): Combinatorial Expression of α- and γ-Protocadherins Alters Their Presenilin-Dependent Processing. Mol Cell Biol, 27/11: 4121–4132
  
04/07Schreiner A et al. (2007): Junction protein Shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. Mol Biol Cell, 18/4:1272-81
  
02/07Chan CHF et al. (2007): Colorectal Hyperplasia and Dysplasia Due to Human Carcinoembryonic Antigen (CEA) Family Member Expression in Transgenic Mice. PLoS ONE, 2/12: e1353
  
01/07Viswanathan A et al. (2007): Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells. Stem Cells, 25/5:1263-9
  
12/06Weinberg AD et al. (2006): Anti-OX40 (CD134) Administration to nonhuman primates: immunostimulatory effects and toxicokinetic study. J Immunother, 29/6: 575-585
  
11/06Ellies D et al. (2006): Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res, 21/11:1738-49
  
10/06D'Amour K et al (2006): Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells. Nat Biotechnol, 24/1: 1392-1401
  
09/06Maraqa L. et al (2006): CEACAM: A potential novel predictor of breast cancer recurrence. AACR Meeting Abstracts 2006 : PR-8
  
09/06Technology Feature: 'Chain gang' delivers for hard labor. Nature Methods, 3/9: 753-762
  
05/06Tsutsumida H et al (2006): RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res, 12: 2976-87
  
04/06Krause S et al. (2006): Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor α1. Mol Immunol, 33/11: 1799-1807
  
04/06Avadhanula V et al. (2006): Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J Virol, 80/4: 1629–1636
  
03/06Nöckel J et al (2006): Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene. BMC Cancer, 6: 57
  
02/06Pavoni E et al. (2006): Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein. BMC Cancer, 6: 41
  
11/05Klaile E et al (2005): CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. JCS, 118: 5513-5524
  
11/05Bade B et al (2005): Differential expression of the granzymes A, B, K, M and perforin in human peripheral blood lymphocytes. Int. Immunol, 17: 1419-1428
  
10/05D’Amour K et al. (2005): Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol, 23: 1534-1541
  
10/05Bratke K et al (2005): Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol, 35/9: 2608-2616
  
10/05Bade B et al. (2005): Detection of soluble human granzyme K in vitro and in vivo. Eur J Immunol, 35/10:2940-2948
  
09/05Roessler et al (2005): Identification of Nicotinamide N-Methyltransferase as a Novel Serum Tumor Marker for Colorectal Cancer. Clin Cancer Res, 11/18: 6550-6558
  
08/05Muenzner P et al (2005): CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. J Cell Biol, 170/5: 825-836
  
04/05Kalina T et al (2005): Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. BMC Cancer 5: 38
  
04/05Kunii R et al. (2005): Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13. J Periodontal Res, 40/2:138-46
  
12/04Nanda A et al. (2004): Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res, 64: 8507–8511
  
10/04Kammerer R et al. (2004): The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma. J Pathol, 204/3: 258-267.
  
09/04Haynes C and BS Schnierle (2004): Retroviral vector targeting through insertion of epidermal growth factor into receptor binding deficient influenza A hemagglutinin results in fusion defective particles. J Virol Methods, 120/2: 189-199
  
09/04Kiessling J et al. (2004): Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm. EMBO reports 5 /9: 889-894
  
08/04Myrtek D et al. (2004): Expression of interleukin-13 receptor a 1-subunit on peripheral blood eosinophils is regulated by cytokines. Immunology, 112: 597–604
  
05/04McCaw S et al. (2004): Engulfment of Neisseria gonorrhoeae: Revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors. Infection and Immunity, 72/5: 2742–2752
  
01/04Schmitter T et al. (2004): Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. J Exp Med, 199/1: 35–46.
  
01/04Elagoz A et al. (2004): A truncated form of CKb8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. Br J Pharmacol, 141/1: 37-46.
  
01/04Bharti S (2004): Novel membrane protein shrew-1 targets to Cadherin-mediated junctions in polarized epithelial cells. Mol Biol Cell, 15: 397–406.
  
12/03Fahlgren A et al. (2003): Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence. Scand J Immunol, 58/6:628-641.
  
11/03de Jonge MI et al. (2003): Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors. Mol Microbiol, 50/3: 1005
  
10/03A shortcut from genomics to drug development. By Jens Lohrmann, Stefan Lang and John Thompson, published in Current Drug Discovery, October 2003. (For reprints please contact Dr. Stefan Lang.)
  
05/03de Jonge MI et al. (2003): Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitides. Infection and Immunity, 71/5:2331-2340
  
02/03Custom-made Antibodies Produced by Genetic Immunisation: Applications in Drug Development, Therapy and Diagnosis. By Stefan Lang and John Thompson, published in Global Outsourcing Review, Vol. 5, No. 1, Spring 2003. (For reprints please contact Dr. Stefan Lang.)
  
12/02Genetische Immunisierung zur Antikörperproduktion. Von Stefan Lang und John Thompson, veröffentlicht in transkript, 12/02, 8.Jahrgang. (Text only in German. For reprints please contact Dr. Stefan Lang.)
  
10/02Bioprocessing - Genetic Immunization for Antibody Production. Tutorial: Genovac's Technological Shortcut From Gene to Antibody. By John Thompson, Ph.D., and Stefan Lang, Ph.D., published in Genetic Engineering News, Vol. 22, No. 17, October 1, 2002 (For reprints please contact Dr. Stefan Lang.)
  
10/02Klippel S et al. (2002): Biochemical characterisation of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. Blood, 100/7: 2441-2448
  
09/02Genetische Immunisierung – ein hocheffizientes Verfahren zur Antikörper-Herstellung für die medizinische Diagnostik und Therapie. Von Stefan Lang und John Thompson, veröffentlicht in BIOspektrum, Sonderausgabe Proteomics & Drug Development, 8.Jahrgang. (Text only in German. For reprints please contact Dr. Stefan Lang.)
  
08/02Bioprocessing - Capacity Mismatch for Production of Monoclonals: Development-Stage Enhancements Alleviate Bottleneck. By Angelo DePalma, Ph.D., published in Genetic Engineering News, Vol. 22, No. 14, August 2002 (For reprints please contact Dr. Stefan Lang.)
  
04/02Billker O et al. (2002): Distinct mechanisms of internalisation of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Pac1- and Cdc42-dependent and –independent pathways. EMBO J, 21/4: 560-571
  
03/02Boulton IC and SD Gray-Owen (2002): Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nat Immunol, 3/3:229-236
  
09/01Watt SM et al. (2001): Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood, 98/5: 1469-1479
  
09/01Richter G. et al. (2001): Tumor necrosis factor -alpha regulates the expression of ICOS ligand on CD34+ progenitor cells during differentiation into antigen presenting cells. J Biol Chem, 276/49: 45686-93
  
04/00Temerinac S et al. (2000): Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. Blood, 95/8: 2569-2576
  
02/00Schoelzel S et al. (2000): Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol, 156/2: 595-605
  
 
   
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